There is no difference on what I think they both have the same meaning " choise " is an obsolete way to spell choice. and an example of. choise (plural choises). Obsolete spelling of choice [quotations ▽]. , Mrs. Thomson, Memoirs of the Jacobites of and Since this then is plainly. Choice definition, an act or instance of choosing; selection: Her choice of a computer was made after months of research. His parents were not happy with his.